This chapter describes the potential far‐reaching consequences of contemplative higher education for the fields of science and medicine.

We introduce a dynamic model for evolutionary games played on a network where strategy changes are correlated according to degree of influence between players. Unlike the notion of stochastic stability, which assumes mutations are stochastically independent and identically distributed, our framework allows for the possibility that agents correlate their strategies with the strategies of those they trust, or those who have influence over them. We show that the dynamical properties of evolutionary games, where such influence neighborhoods appear, differ dramatically from (...) those where all mutations are stochastically independent, and establish some elementary convergence results relevant for the evolution of social institutions. (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

Aim: Patients with advanced cancer need information about end-of-life treatment options in order to make informed decisions. Clinicians vary in the frequency with which they initiate these discussions.Patients and methods: As part of a long-term longitudinal study, patients with an expected 2-year survival of less than 50% who had advanced gastrointestinal or lung cancer or amyotrophic lateral sclerosis were interviewed. Each patient’s medical record was reviewed at enrollment and at 3 months for evidence of the discussion of patient wishes concerning (...) ventilator support, artificial nutrition and hydration , resuscitation and hospice care. A Kaplan–Meier analysis was also performed and 2-year survival calculated.Results: 60 cancer and 32 ALS patients were enrolled. ALS patients were more likely than cancer patients to have evidence of discussion about their wishes for ventilator support , ANH , DNR and hospice care . At 6 months, 91% of ALS patients were alive compared with 62% of cancer patients; at 2 years, 63% of ALS patients were alive compared with 23% of cancer patients .Conclusions: Cancer patients were less likely than ALS patients to have had documented advanced care planning discussions despite worse survival. This may reflect perceptions that ALS has a more predictable course, that advanced cancer has a greater number of treatment options, or differing views about hope. Nevertheless, cancer patients may be less adequately prepared for end-of-life decision-making. (shrink)

Sahip olduğu akademik imkânların ve başta İngilizce olmak üzere birçok dilde uluslararası yayınların çokluğu nedeniyle Amerika Birleşik Devletleri’ndeki İslam çalışmaları yoğun, üretken ve dünya genelinde ilgiyle takip edilen bir alandır. Ancak Batı’daki üniversitelerin genelinde olduğu gibi Amerikan üniversitelerinde de İslam felsefesi/tarihi çalışmaları oldukça zayıftır. Bu makalede öncelikle geçmişten günümüze İslam çalışmalarının ABD’deki durumu tasviri bir metotla ortaya konulmakta ve İslam Felsefesinin ABD’deki İslam çalışmaları içerisindeki zayıf konumu sorgulanmaktadır. İkinci olarak Post-Oryantalist süreçte İslam Felsefesi çalışmalarında öne çıkan isimler ve çalışmaları değerlendirilmektedir. (...) Sonuç olarak ABD üniversite sisteminin genel yapısının gereği olarak İslam Felsefesi çalışmaları nicelik bakımından Avrupa ve İslam coğrafyasından daha zayıf olduğu görülmektedir. Bu durumu iki şekilde açıklamak mümkündür. Birincisi alanın Amerikan devlet felsefesinin temel ilkesi olan bilgi-güç hedefi ve alanın politik çıkarlarıyla ilişkisinin zayıflığıdır. Bu durum Post-Oryantalist eğilimin arka planını da oluşturmaktadır. İkincisi ise fenomenolojist yönteme olan ilginin artması ve Amerikan yükseköğretim sisteminde hâkim olan kozmopolitanizm ve interdisiplinerci yaklaşımlardır.Özet: Dünyanın önde gelen üniversitelerinde İslam çalışmaları ve bu çalışmalar içerisinde yer alan İslam felsefesi çalışmalarının önemli bir akademik ilgi alanı olduğu görülmektedir. Bu ilgi ABD’de de yaklaşık 150 yıllık bir geçmişe sahiptir. Son yıllarda Amerika Birleşik Devletleri’nde İslam çalışmalarında sadece ciddi bir artış değil aynı zamanda çeşitlenme de söz konusu olmuştur. ABD’deki İslam çalışmaları ve özelde İslam felsefesi çalışmalarının durumunu birlikte ele alan akademik araştırmalar ise henüz bulunmamaktadır. Son gelişmeleri de dikkate alarak alanla ilgili araştırmaların sürdürülmesi ve İslam felsefesi çalışmalarının da noksan bırakılan izinin sürülmesi gerekmektedir. Bu noktadan hareketle bu makale çalışması, üniversite müfredatlarıyla ilgili araştırmalar, web taramaları ve yazılı materyaller üzerinden gerçekleştirilecek ve ilgili kitaplar, makaleler ve diğer kaynaklar taranarak konu hakkında deskriptif bilgiler sunulacaktır. Bu yöntemin tercih edilme nedeni derinlemesine bir araştırmadan daha çok genel resmi ortaya koymak ve mevcut durum hakkında bilgi vermektir. Sahanın genişliği ve kaynakların çeşitliliği ve konunun daha özel ve yoğun bir çalışma gerektiren yapısı nedeniyle diğer yöntemler tercih edilmemiştir Çalışma iki ana başlıktan oluşmaktadır. Birincisi ABD’deki İslam çalışmalarının konumu ile ilgilidir. Bu başlık altında 18. yüzyıldan itibaren İslam çalışmalarının ABD’deki seyri hakkında bilgi verilmekte ve İslam çalışmalarının günümüzdeki konumu detaylandırılmaktadır. İkinci başlık İslam Felsefesi çalışmalarının İslam çalışmaları içerisindeki ve ABD akademilerindeki konumuyla ilgilidir. Bu başlık altında İslam Felsefesi çalışmalarının geçmişten günümüze kadar gelinen süreçte geçirdiği evreler tasvir edilmekte ve bazı isimlerin ve eserlerinin değerlendirmesi yapılmaktır. İncelemeler sonucunda ABD’deki İslam çalışmalarının geçmişinin yaklaşık 150 yıla tekabül etmesine rağmen yeterli seviyeye ulaşmadığı görüldü. Hâlbuki sahip olduğu Müslüman nüfus, akademik imkânlar ve başta İngilizce olmak üzere birçok dilde uluslararası yayınların çokluğu nedeniyle ABD’deki İslam çalışmalarının beklenenden daha yoğun, üretken olması beklenirdi. Ancak buna rağmen Daha çok Fenomenolojist ve İnterdisipliner yaklaşımın tercih edildiği Amerikan üniversitelerinin akademik kadro çeşitliliği ve başta İngilizce olmak üzere farklı dillerdeki yayın yelpazesinin genişliği ve son yıllarda yeni bir durum olan sosyal medyaya açık akademik faaliyetler ABD’nin İslam çalışmaları alanındaki etkinliğini giderek arttırmaktadır. Geçmişte İslam çalışmalarında öncü rolü oynayan İngiltere, Fransa, Almanya ve Hollanda gibi ülkelerde öteden beri oryantalist eğilimi temsil eden bu tür çalışmalar günümüz ABD üniversitelerinde interdisipliner ve multidisipliner bir format kazarak devam etmektedir. ABD’deki İslam çalışmaları üzerinde yoğunlaşan akademik çalışmalara göre İslam çalışmalarına yön veren en önemli etken oryantalist eğilimlerdir. Bunun yanında 11 Eylül olaylarının sonucunda da artan bir ilgiden söz etmek gerekmektedir. Bu ilgi sadece alanda yeni istihdam imkânlarının oluşmasına değil aynı zamanda araştırmacı sayısının da artmasına neden olmuştur. Çalışmamın ikinci kısmını oluşturan ABD üniversitelerindeki İslam felsefesi çalışmalarının genel durumuna bakılacak olursa bu çalışmaların sosyoloji, antropoloji ve kültür çalışmaları gibi alanlarda görülen çeşitliliğe de sahip olduğunu söylemek oldukça zordur. ABD üniversitelerindeki İslam felsefesi çalışmaları İslam çalışmaları genel çatısı altında sürdürülmektedir. Bu alandaki çalışmalar başlarda daha çok oryantalist eğilimi temsil eden Philip Hittî, Leo Strauss, Muhsin Mehdî, Fazlurrahmân, İsmâil Râci Fârukî, Mâcid Haddûrî, Moshe Pearlmann, gibi önemli isimler tarafından sürdürülmekteydi. Günümüzde Charles Butterworth, Seyyid Hüseyin Nasr, Oliver Leaman, Dimitri Gutas, Robert Wisnovsky, Frank Griffel, John Walbridge ve daha birçok isim yeni eğilimin temsilcileri olarak alanla ilgili çalışmalarını sürdürmektedir. Bu araştırmacılar, Amerikan akademik siteminin bir sonucu olarak sadece İslam felsefesi değil aynı zamanda İslam bilim tarihi, İslam tarihi ve medeniyeti, İslam ve Batı vb. alanlarda da yayınlar yapmakta ve İslam çalışmalarının sürdürüldüğü çeşitli üniversitelerde dersler vermekte ve lisansüstü seviyede öğrenciler yetiştirmektedir. Bu noktadan hareketle diyebiliriz ki İslam felsefesi çalışmaları ise diğer İslam çalışmalarına kıyasla daha da zayıftır. Bu durumun sebeplerini şu şekilde açıklamak mümkündür:1-Amerikan devlet felsefesinin temel ilkesi olan bilgi-güç hedefi ve alanın politik çıkarlarıyla ilişkisinin zayıflığı. Bilimlerle kurulan bu politik çıkar ilişkisi Post-Oryantalist eğilimin arka planını da oluşturmaktadır. 2-Amerikan Üniversitelerinde fenomenolojist yönteme olan ilginin artması ve Amerikan yükseköğretim sisteminde hâkim olan kozmopolitanizm ve interdisiplinerci yaklaşımlar.3-Amerikan üniversitelerindeki Yakın Doğu, Ortadoğu ve İslam Çalışmalarında İslam felsefesi dersleri felsefenin ya da felsefe tarihinin bir parçası olarak müfredatta yer alması. Amerikan üniversitelerinde standart müfredat sistemi yaygın olmadığından İslam felsefesi ile ilgili dersler bölümden daha çok ders veren hocanın ilgisine ve isteğine bağlı olarak verilmektedir.4-Kıta Avrupası’nda görülen katı oryantalist eğilimlerin nisbeten azlığı ve ABD devlet politikalarının gereği olarak şekillenen havuz usulü müfredat.5-Bazı İslam felsefesi uzmanlarının alanı terk ederek daha çok aktüel tartışmalara yönelmesi ve daha çok Müslümanların geri kalmışlığı sorunundan hareketle üretilen problemlere odaklanması. Son olarak İslam felsefesi çalışmaları Müslümanların genelinin ilgilendiği bir disiplin olmadığı için üniversite dışında İslam felsefesi çalışmalarının yürütüldüğü kurumsal yapılar ABD’de de henüz teşekkül etmemiştir. Bazı bölümlerde İslam Felsefesi İslam düşüncesi tarihinin bir alt dalı olarak varlığını sürdürmektedir. Ancak İslam felsefesi müstakil bir alan olarak kendisine henüz ABD üniversitelerinde yer bulamamıştır. USA’da artan İslam çalışmalarının yeterli düzeyde olmasa da dünyadaki islam çalışmalarına yön verebilecek noktaya ulaştığını söylemek mümkündür. (shrink)

This is a study of a crucial and controversial topic in metaphysics and the philosophy of science: the status of the laws of nature. D. M. Armstrong works out clearly and in comprehensive detail a largely original view that laws are relations between properties or universals. The theory is continuous with the views on universals and more generally with the scientific realism that Professor Armstrong has advanced in earlier publications. He begins here by mounting an attack on the orthodox and (...) sceptical view deriving from Hume that laws assert no more than a regularity of coincidence between instances of properties. In doing so he presents what may become the definitive statement of the case against this position. Professor Armstrong then goes on to establish his own theory in a systematic manner defending it against the most likely objections, and extending both it and the related theory of universals to cover functional and statistical laws. This treatment of the subject is refreshingly concise and vivid: it will both stimulate vigorous professional debate and make an excellent student text. (shrink)

In this short text, a distinguished philosopher turns his attention to one of the oldest and most fundamental philosophical problems of all: How it is that we are able to sort and classify different things as being of the same natural class? Professor Armstrong carefully sets out six major theories—ancient, modern, and contemporary—and assesses the strengths and weaknesses of each. Recognizing that there are no final victories or defeats in metaphysics, Armstrong nonetheless defends a traditional account of universals as the (...) most satisfactory theory we have.This study is written for advanced students, but as Armstrong goes considerably beyond his earlier work on this topic, it will interest professional scholars as well. Carefully plotted and clearly written, Universals is both a paradigm of exposition and a case study on the value of careful analysis of fundamental issues in philosophy. (shrink)

Breaking new ground in the debate about the relation of mind and body, David Armstrong's classic text - first published in 1968 - remains the most compelling and comprehensive statement of the view that the mind is material or physical. In the preface to this new edition, the author reflects on the book's impact and considers it in the light of subsequent developments. He also provides a bibliography of all the key writings to have appeared in the materialist debate.

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

Truths are determined not by what we believe, but by the way the world is. Or so realists about truth believe. Philosophers call such theories correspondence theories of truth. Truthmaking theory, which now has many adherents among contemporary philosophers, is the most recent development of a realist theory of truth, and in this book D. M. Armstrong offers the first full-length study of this theory. He examines its applications to different sorts of truth, including contingent truths, modal truths, truths about (...) the past and the future, and mathematical truths. In a clear, even-handed and non-technical discussion he makes a compelling case for truthmaking and its importance in philosophy. His book marks a significant contribution to the debate and will be of interest to a wide range of readers working in analytical philosophy. (shrink)

A wide-ranging study of the central concepts in epistemology - belief, truth and knowledge. Professor Armstrong offers a dispositional account of general beliefs and of knowledge of general propositions. Belief about particular matters of fact are described as structures in the mind of the believer which represent or 'map' reality, while general beliefs are dispositions to extend the 'map' or introduce casual relations between portions of the map according to general rules. 'Knowledge' denotes the reliability of such beliefs as representations (...) of reality. Within this framework Professor Armstrong offers a distinctive account of many of the main questions in general epistemology - the relations between beliefs and language, the notions of proposition, concept and idea, the analysis of truth, the varieties of knowledge, and the way in which beleifs and knowledge are supported by reasons. The book as a whole if offered as a contribution to a naturalistic account of man. (shrink)

This is a collection of twenty-five papers and reviews by the leading analytic philosopher of our time. It adds to the papers on metaphysics and epistemology to be found in his previous two-volume collection published by Oxford University Press. One previously unpublished paper—“Why Conditionalize?”—is included. Australasian philosophers may note with some pride that eleven of the pieces were first published in the Australasian Journal of Philosophy.

First, The doctrine of naturalism, That reality is spatio-Temporal, Is defended. Second, The doctrine of materialism or physicalism, That this spatio-Temporal reality involves nothing but the entities of physics working according to the principles of physics, Is defended. Third, It is argued that these doctrines do not constitute a "first philosophy." a satisfactory first philosophy should recognize universals, In the form of instantiated properties and relations. Laws of nature are constituted by relations between universals. What universals there are, And what (...) relations hold between them, Must be discovered "a posteriori" by scientific investigation. (shrink)

D. M. Armstrong; II—Does Knowledge Entail Belief?, Proceedings of the Aristotelian Society, Volume 70, Issue 1, 1 June 1970, Pages 21–36, https://doi.org/10.109.

Argues that a set is the mereological whole of the singleton sets of its members (following Lewis's Parts of Classes), and that the singleton set of X is the state of affairs of X's having some unit-making property.

Dispositions are essential to our understanding of the world. IDispositions: A Debate is an extended dialogue between three distinguished philosophers - D.M. Armstrong, C.B. Martin and U.T. Place - on the many problems associated with dispositions, which reveals their own distinctive accounts of the nature of dispositions. These are then linked to other issues such as the nature of mind, matter, universals, existence, laws of nature and causation.

It is not certain when or by whom S0009838800011642_inline1 and S0009838800011642_inline2 were first technically distinguished as genus and species. The distinction does not appear in Plato's extant writings, whereas Aristotle seems to take it for granted in the Topics, which is usually regarded as among his earliest treatises. In his dialogues Plato seems able to use S0009838800011642_inline3 interchangeably to denote any group or division in a diairesis, including the group that is to be divided.

We argue that heritability estimates cannot be used to make informed judgments about the populations from which they are drawn. Furthermore, predicting changes in heritability from population changes is likely impossible, and of limited value. We add that the attempt to separate human environments into cultural and non-cultural components does not advance our understanding of the environmental multiplier effect.

It is not certain when or by whomandwere first technically distinguished asgenusandspecies. The distinction does not appear in Plato's extant writings, whereas Aristotle seems to take it for granted in theTopics, which is usually regarded as among his earliest treatises. In his dialogues Plato seems able to useinterchangeably to denote any group or division in a diairesis, including the group that is to be divided.

I want to defend a Combinatorialtheory of possibility. Such a view traces the very idea of possibility to the idea of the combinations – all the combinations which respect a certain simple form – of given, actual, elements. Combination is to be understood widely enough to cover the notions of expansion and contraction. The combinatorial idea is not new, of course. Wittgenstein gave a classical exposition of it in the Tractatus. Perhaps its charter is 3.4: ‘A proposition determines a place (...) in logical space. The existence of this logical place is guaranteed by the mere existence of the constituents’. There is a small additional combinatorial literature. I myself was converted to a combinatorial view by Brian Skyrms’ brief but fascinating article ‘Tractarian Nominalism.’. (shrink)

It is not certain when or by whomandwere first technically distinguished asgenusandspecies. The distinction does not appear in Plato's extant writings, whereas Aristotle seems to take it for granted in theTopics, which is usually regarded as among his earliest treatises. In his dialogues Plato seems able to useinterchangeably to denote any group or division in a diairesis, including the group that is to be divided.

The purpose of this research is to examine the effect of two organizational variables, budget goal difficulty and promotion availability, on employee fraud. Limited research shows that difficult, specific goals result in more unethical behavior than general goals :422–432, 2004). We predict that goal difficulty and promotion availability will interact to affect employee fraud. Specifically, we contend that the availability of promotions will have little, if any, effect on employee fraud under easy goals but have a substantial effect on fraud (...) under extremely difficult goals. To test this prediction, we use an experiment in which participants play the role of production employees. All participants are assigned cost goals and are responsible for reporting costs to the organization. Information asymmetry exists such that the organization is unable to assess whether costs have been reported accurately, and any overstatement of costs directly increases the employee’s compensation at the expense of the organization. The results of our experiment support the prediction, even though the cost goal is not tied to current period compensation. Our results have implications for academics and practitioners concerned with factors that affect fraud in organizations. (shrink)

Words form a fundamental basis for our understanding of linguistic practice. However, the precise ontology of words has eluded many philosophers and linguists. A persistent difficulty for most accounts of words is the type-token distinction [Bromberger, S. 1989. “Types and Tokens in Linguistics.” In Reflections on Chomsky, edited by A. George, 58–90. Basil Blackwell; Kaplan, D. 1990. “Words.” Aristotelian Society Supplementary Volume LXIV: 93–119]. In this paper, I present a novel account of words which differs from the atomistic and (...) platonistic conceptions of previous accounts which I argue fall prey to this problem. Specifically, I proffer a structuralist account of linguistic items, along the lines of structuralism in the philosophy of mathematics [Shapiro, S. 1997. Philosophy of Mathematics: Structure and Ontology. Oxford University Press], in which words are defined in part as positions in larger linguistic structures. I then follow Szabò [1999. “Expressions and Their Representations.” The Philosophical Quarterly 49 (195): 145–163] and Parsons [1990. “The Structuralist View of Mathematical Objects.” Synthese 84: 303–346] in further defining words as quasi-concrete objects according to a representation relation. This view aims for general correspondence with contemporary generative linguistic approaches to the study of language. (shrink)

The central insight of Darwin's Origin of Species is that evolution is an ecological phenomenon, arising from the activities of organisms in the 'struggle for life'. By contrast, the Modern Synthesis theory of evolution, which rose to prominence in the twentieth century, presents evolution as a fundamentally molecular phenomenon, occurring in populations of sub-organismal entities - genes. After nearly a century of success, the Modern Synthesis theory is now being challenged by empirical advances in the study of organismal development and (...) inheritance. In this important study, D. M. Walsh shows that the principal defect of the Modern Synthesis resides in its rejection of Darwin's organismal perspective, and argues for 'situated Darwinism': an alternative, organism-centred conception of evolution that prioritises organisms as adaptive agents. His book will be of interest to scholars and advanced students of evolutionary biology and the philosophy of biology. (shrink)

The role of the environment in producing the correct classical limit in the Bohm interpretation of quantum mechanics is investigated, in the context of a model of quantum Brownian motion. One of the effects of the interaction is to produce a rapid approximate diagonalisation of the reduced density matrix in the position representation. This effect is, by itself, insufficient to produce generically quasi-classical behaviour of the Bohmian trajectory. However, it is shown that, if the system particle is initially in an (...) approximate energy eigenstate, then there is a tendency for the Bohmian trajectory to become approximately classical on a longer time-scale. The relationship between this phenomenon and the behaviour of the Wigner function post-decoherence is discussed. (shrink)

Analyzes difficult case in the theory of truthmaking. Account on the notion of a truthmaker by philosopher Bertrand Russell; Context of the correspondence theory of truth; Requisites of a truthmaker; Discussion on negative truths, universally quantified truths and modal truths.